Bernard Korzeniewski
Bernard Korzeniewski
Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387 Kraków (Krakow), Poland
e-mail: benio@mol.uj.edu.pl
tel. (48 12) 664 63 73
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Computer modelling of oxidative phosphorylation in isolated mitochondria, intact skeletal muscle and heart; regulation of ATP supply during an increased energy demand (the 'each-step activation' proposal: all steps of oxidative phosphorylation are directly activated in parallel with ATP consumption by some external factor during an increased energy demand in muscle); effect of low oxygen concentration on oxidative phosphorylation; effect of inborn enzyme deficincies on oxidative phosphorylation, genesis of mitochondrial diseases; cybernetic definition of life.
1. B Korzeniewski, M-E Harper, MD Brand (1995) Proportional activation coefficients during stimulation of oxidative phosphorylation by lactate and pyruvate or by vasopressin. Biochim. Biophys. Acta 1229, 315-322.
2. B Korzeniewski, J-P Mazat (1996) Theoretical studies on the control of oxidative phosphorylation in muscle mitochondria: application to mitochondrial deficiencies. Biochem J 319, 143-148.
3. B Korzeniewski (1998) Regulation of ATP supply during muscle contraction: theoretical studies. Biochem. J. 330, 1189-1195.
4. B Korzeniewski (2001) Cybernetic formulation of the definition of life. J. Theor. Biol. 209, 275-286.
5. B Korzeniewski, JA Zoladz (2001) A model of oxidative phosphorylation in mammalian skeletal muscle. Biophys. Chem. 92, 17-34.
6. B Korzeniewski, JA Zoladz (2003) Training-induced adaptation of oxidative phosphorylation in skeletal muscle. Biochem. J. 374, 37-40.
7. B Korzeniewski (2003) Regulation of oxidative phosphorylation in different muscles and various experimental conditions. Biochem. J. 375, 799-804.
8. B Korzeniewski, JA Zoladz (2004) Factors determining the oxygen consumption rate (VO2) on-kinetics in skeletal muscle. Biochem. J. 379, 703-710.
9. B Korzeniewski, A Noma, S Matsuoka (2005) Regulation of oxidative phosphorylation in intact mammalian heart in vivo. Biophys. Chem. 116, 145-157.
10. B Korzeniewski (2005) Confrontation of the cybernetic definition of a living individual with the real world. Acta Biotheor. 53, 1-28.
11. B Korzeniewski (2006) AMP deamination delays muscle acidification during heavy exercise and hypoxia. J. Biol. Chem. 281, 3057-3066.
12. B Korzeniewski (2006) Oxygen consumption and metabolite concentrations during transitions between different work intensities in heart. Am. J. Physiol. 291, H1466-H1474.
13. Liguzinski P, Korzeniewski B (2006) Metabolic control over the oxygen consumption flux in intact skeletal muscle: in silico studies. Am J Physiol 291, 1213-1224..
14. Liguzinski P, Korzeniewski B (2007) Oxygen delivery by blood determines the maximal VO2 and work rate during whole body exercise in humans: in silico studies. Am J Physiol 293, H343-H353.
15. Korzeniewski B (2007) Regulation of oxidative phosphorylation through parallel activation. Biophys Chem 129, 93-110.
16. Korzeniewski B, Deschodt-Arsac V, Calmettes G, Franconi J-M, Diolez P (2008) Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply. Biochem J 413, 343-347 .
17. Dzbek J, Korzeniewski B (2008) Control over the contribution of the mitochondrial membrane potential (DY) and proton gradient (DpH) to the protonmotive force (Dp): In silico studies. J Biol Chem 283, 33232-33239.
